More than 5000 active chemicals with high quality for research!

Email sales@dcchemicals.com



Phone:  +86-21-58447131

Fax   +86-21-61642470

DC12081  (CAS:1231220-79-3)
(Based on popularity)
Size Price Availability
100mg USD 750 in stock
250mg USD 1300 in stock
1g USD 2700 in stock
We match the best price and quality on market.
Email: order@dcchemicals.com
Tel: +86-21-58447131
Fields of Application :
LY2828360 is a slowly acting but efficacious G protein-biased cannabinoid (CB2) agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling.
CAS Number: 1231220-79-3

Molecular Weight: 426.94
Molecular Formula: C22H27ClN6O
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
In Vivo In WT mice, acute systemic administration of LY2828360 suppresses paclitaxel-induced mechanical and cold allodynia in a dose-dependent manner. LY2828360 produces time-dependent suppressions of paclitaxel-evoked mechanical and cold hypersensitivities and suppression of allodynia is maintained for at least 4.5 h post-injection relative to drug pre-injection levels. At 24 h post-injection, paclitaxel-induced mechanical allodynia has returned to drug pre-injection levels of hypersensitivity. Residual suppression of cold allodynia was absent by 72 h post LY2828360 treatment. Previously chronic administration of LY2828360 blocks the development of tolerance to the antiallodynic effects of morphine in WT but not in CB2KO mice. Chronic LY2828360 treatment suppresses paclitaxel-induced mechanical and cold allodynia in WT mice but not in CB2KO mice previously render tolerant to morphine.
About us Products Services ordering sitemap
Phone: +86-21-58447131Fax: +86-21-61642470
ADDRoom 610, Building 15, Jinxiang Rd 201, Pudong,Shanghai, China
CopyRight-2010-2013 DC Chemicals All Rights Reserved