Fmoc-Val-Ala-PAB-OH

  Cat. No.:  DC39235   Featured
Fmoc-Val-Ala-PAB-OH
Chemical Structure
1394238-91-5
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Field of application
Fmoc-Val-Ala-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Cas No.: 1394238-91-5
Chemical Name: (9H-fluoren-9-yl)methyl (S)-1-((S)-1-(4-(hydroxymethyl)phenylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate
Synonyms: Fmoc-Val-Ala-PAB; ACD linker; Fmoc-Val-Ala-PAB-OH
SMILES: C[C@@H](C(N)=O)N(C([C@H](C(C)C)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)=O)C4=CC=C(CO)C=C4
Formula: C30H33N3O5
M.Wt: 515.60
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC50025 Deruxtecan Deruxtecan, a topoisomerase I inhibitor, is an exatecan derivative (DX-8951 derivative) with a cleavable pepetide linker and a maleimide group. The maleimide group in Deruxtecan can react with antibody to form antibody-drug conguates (ADC) such as Trastuzumab deruxtecan (DS-8201a), which is a HER2-targeting antibody–drug conjugate.
DC39235 Fmoc-Val-Ala-PAB-OH Fmoc-Val-Ala-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).