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Tyk2-IN-4(BMS986165)
DC12174  (CAS:1609392-27-9)
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Fields of Application :
Tyk2-IN-4 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2).
CAS Number: 1609392-27-9
Purity:

Molecular Weight: 425.46
Molecular Formula: C20H19D3N8O3
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: Tyk2-IN-4,BMS986165,BMS-986165,BMS 986165
Chemical Name: 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2, 4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
In Vitro Tyk2-IN-4 blocks receptor-mediated Tyk2 activation by stabilizing the regulatory pseudokinase domain of the protein. In Vivo Lupus-like disease is strongly inhibited in NZB/W mice treated with Tyk2-IN-4. Tyk2-IN-4 is safe and overall well-tolerated. There are no serious adverse events and the frequency of non-serious adverse events are similar in the active (75%) and placebo (76%) groups. After oral administration, Tyk2-IN-4 is rapidly absorbed and exhibits an apparent elimination half-life of 8-15 hours.
References:
O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[2H]
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