IACS-10759 Hydrochloride

  Cat. No.:  DC12105  
IACS-10759 Hydrochloride
Chemical Structure
1807523-99-4
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More than 5000 active chemicals with high quality for research!
Field of application
IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS).
Cas No.: 1807523-99-4
Chemical Name:
Synonyms:
SMILES: FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC(N5CCC(S(=O)(C)=O)CC5)=CC=C4)C(C)=N3)=N2)C=C1.Cl
Formula: C25H26ClF3N6O4S
M.Wt: 599.02
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: In Vitro IACS-10759 inhibits the conversion of NADH to NAD+ in an immunoprecipitated complex I assay at low nM concentrations. In Vivo IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species and achieves significant in vivo efficacy with daily oral dosing of 10-25 mg/kg. There is a >50 day extension of median survival in an orthotopic AML cell line xenograft and robust regression in DLBCL and GBM xenograft models.
In Vivo:
In Vitro:
References:
Kinase Assay:
Cell Assay:
Animal Administration:
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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