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IACS-10759 Hydrochloride
DC12105  (CAS:1807523-99-4)
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100mg USD 950 in stock
250mg USD 1900 in stock
1g USD 3800 in stock
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Fields of Application :
IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS).
CAS Number: 1807523-99-4
Purity:

Molecular Weight: 599.02
Molecular Formula: C25H26ClF3N6O4S
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms:
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
In Vitro IACS-10759 inhibits the conversion of NADH to NAD+ in an immunoprecipitated complex I assay at low nM concentrations. In Vivo IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species and achieves significant in vivo efficacy with daily oral dosing of 10-25 mg/kg. There is a >50 day extension of median survival in an orthotopic AML cell line xenograft and robust regression in DLBCL and GBM xenograft models.
References:
FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC(N5CCC(S(=O)(C)=O)CC5)=CC=C4)C(C)=N3)=N2)C=C1.Cl
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