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2'3'-cGAMP
DC12367  (CAS:1441190-66-4)
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Fields of Application :
2'3'-cGAMP has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA.
CAS Number: 1441190-66-4
Purity:

>99.5%

Molecular Weight: 710.38
Molecular Formula: C20H22N10O13P2.N2H8
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: Mammalian (non-canonical) CDN, cyclic [G(2,5)pA(3,5)p]
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
23-cGAMP (cyclic [G(2,5)pA(3,5)p]) is produced in mammalian cells by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. 23-cGAMP is also referred to as noncanonical cGAMP due to the presence of the atypical 2-5 phosphodiester linkage between the guanosine and the adenosine. Similar to the canonical 33-cGAMP, 23-cGAMP serves as a second messenger to activate innate immune responses by binding to STING (stimulator of IFN genes) and subsequently inducing the TBK1-IRF3-dependent production of IFN- . Structural and functional studies revealed that noncanonical 23-cGAMP is distinct from the canonical 33-cGAMP produced by bacteria. 2'3'-cGAMP binds to STING with a much greater affinity than 3'3'-cGAMP. Certain variants of STING are able to distinguish between noncanonical and canonical cGAMP.
References:
C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3NC(=NC4=O)N)OP(=O)(OC[C@@H]5[C@H]([C@H]([C@@H](O5)N6C=NC7=C6N=CN=C7N)O)OP(=O)(O1)O)O)O
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