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LOM612
DC12142  (CAS:2173232-79-4)
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Fields of Application :
LOM612 is a potent activator of FOXO nuclear translocation, with an EC50 value of 1.5 M in cells.
CAS Number: 2173232-79-4
Purity:

Molecular Weight: 258.3
Molecular Formula: C13H10N2O2S
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms:
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
In Vitro LOM612 potently activates nuclear translocation of FOXO with an EC50 value of 1.5 M, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC50 value of 0.64 M, and does not sensitize non-cancer THLE2 cells (IC50, 2.76 M).
References:
O=C1C2=C(SN=C2N(C)C)C(C3=CC=CC=C31)=O
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