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4SC-202 free base
DC8423  (CAS:910462-43-0)
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100mg USD 600 In stock
250mg USD 1000 In stock
1g USD 1800 In stock
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Fields of Application :
4SC-202 is a selective class I HDAC inhibitor with IC50 of 1.20 M, 1.12 M, and 0.57 M for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.
CAS Number: 910462-43-0
Purity:

>98%

Molecular Weight: 447.51
Molecular Formula: C23H21N5O3S
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: 4SC-202,4SC 202,4SC202
Chemical Name: (E)-N-(2-aminophenyl)-3-(1-(4-(1-methyl-1H-pyrazol-4-yl)phenylsulfonyl)-1H-pyrrol-3-yl)acrylamide
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
In HeLa cells, 4SC-202 induces hyperacetylation of histone H3 with EC50 of 1.1 M. 4SC-202 induces a G2/M cell cycle arrest by interfering with the normal development of the mitotic spindle and causing collapsed spindle apparatus and multiple nucleation centres. In addition, 4SC-202 shows a broad anti-proliferative activity towards human cancer cell lines with a mean IC50 of 0.7 M. In vivo, 4SC-202 has a high oral bioavailability, and shows high metabolic stability and a low plasma clearance. 4SC-202 (120 mg/kg p.o.) shows pronounced and robust anti-tumor activity in both A549 NSCLC xenograft and RKO27 colon carcinoma model. For the detailed information of 4SC-202, the solubility of 4SC-202 in water, the solubility of 4SC-202 in DMSO, the solubility of 4SC-202 in PBS buffer, the animal experiment (test) of 4SC-202, the cell expriment (test) of 4SC-202, the in vivo, in vitro and clinical trial test of 4SC-202, the EC50, IC50,and affinity,of 4SC-202, For the detailed information of 4SC-202, the solubility of 4SC-202 in water, the solubility of 4SC-202 in DMSO, the solubility of 4SC-202 in PBS buffer, the animal experiment (test) of 4SC-202, the cell expriment (test) of 4SC-202, the in vivo, in vitro and clinical trial test of 4SC-202, the EC50, IC50,and affinity,of 4SC-202, Please contact DC Chemicals.
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