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Decursin ((+)-Decursin)
DC12144  (CAS:5928-25-6)
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100mg USD 600 in stock
250mg USD 1100 in stock
1g USD 2300 in stock
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Fields of Application :
Decursin is an anticancer agent, with potential anti-inflammatory activity.
CAS Number: 5928-25-6
Purity:

Molecular Weight: 328.36
Molecular Formula: C19H20O5
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms:
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
In Vitro Decursin (25-100 M) shows a strong dose- and time-dependent inhibition of cell growth, accounting for 22% to 51%, 21% to 68%, 9% to 72%, and 42% to 90% growth inhibition after 24, 48, 72, and 96 hours of treatment, respectively. Furthermore, it is observed that both Decursin and Decursinol have cytotoxic effect on DU145 cells, in which similar treatment (25-100 M for 24, 48, 72, and 96 hours) with Decursin cause 15% to 45% cell death versus 11% to 12% in controls. Decursin blocks tumor progression by suppression of angiopoietin-2, angiopoietin receptor Tie-2, and endothelial nitric oxide synthase (eNOS) in endothelial progenitor cells. Decursin has the ability to inhibit vascular endothelial growth factor (VEGF)-induced proliferation, metastasis, and tube formation in human umbilical vein endothelial cells (HUVECs). Decursin inhibits pro-inflammatory molecules, such as chemokines, cytokines, and enzymes such as Cyclooxygenase-2 (COX-2) and MMPs.
References:
C/C(C)=C\C(O[C@H](C(C)(C)O1)CC2=C1C=C(O3)C(C=CC3=O)=C2)=O
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