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BF 227
DC12131  (CAS:845647-80-5)
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Fields of Application :
BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for A1-42 fibrils.
CAS Number: 845647-80-5
Purity:

Molecular Weight: 333.38
Molecular Formula: C16H16FN3O2S
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms:
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
In Vitro BF-227 has a high binding affinity for A1-42 fibrils. The Ki value for A1-42 fibrils in competitive binding assay using [125I]BF-180 is 4.31.3 nM in BF-227 (Kd value of [125I]BF-180: 10.81.5 nM). [11C]BF-227 is a PET tracer. The AUC for BF-227 (0.994) is much higher than that for FDG (0.839), indicating that BF-227 is more sensitive as well as more specific than FDG in diagnosing AD.
References:
CN(C)C1=NC=C(S1)/C=C/C2=NC3=CC=C(OCCF)C=C3O2
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