More than 5000 active chemicals with high quality for research!

Email sales@dcchemicals.com



Phone:  +86-21-58447131

Fax   +86-21-61642470

DC12230  (CAS:1175526-27-8)
(Based on popularity)
Size Price Availability
100mg USD 850 in stock
250mg USD 1500 in stock
1g USD 3000 in stock
We match the best price and quality on market.
Email: order@dcchemicals.com
Tel: +86-21-58447131
Fields of Application :
AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist
CAS Number: 1175526-27-8

Molecular Weight: 500.51
Molecular Formula: C27H27F3N2O4
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
In Vitro AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively. In the presence of 0.2% serum albumin, AM211 inhibits radiolabeled PGD2 binding to human, mouse, guinea pig, and rat DP2 with IC50 values of 12.2, 20.1, 22.9, and 34.2 nM, respectively. AM211 displays high selectivity for DP2 versus other receptors in the prostanoid family, with IC50 values for the inhibition of radioligand binding to human TP, IP, DP1, and FP of more than 100 M. AM211 (100 M) shows no activity at COX-1, COX-2 enzymes as well as PPAR family of nuclear receptors. In Vivo AM211 (1, 10, and 30 mg/kg, p.o.) dose-dependently decreases in the number of DK-PGD2-induced peripheral blood leukocytes, with a calculated ED50 of 0.85 mg/kg. AM211 (30 mg/kg) also decreases antigen-induced pulmonary inflammation in guinea pigs. AM211 (10 mg/kg, p.o.) causes significant decrease in ovalbumin (OVA)-induced sneezing in a mouse model of allergic rhinitis.
About us Products Services ordering sitemap
Phone: +86-21-58447131Fax: +86-21-61642470
ADDRoom 610, Building 15, Jinxiang Rd 201, Pudong,Shanghai, China
CopyRight-2010-2013 DC Chemicals All Rights Reserved