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AX15836
DC10649  (CAS:N/A)
(Based on popularity)
Size Price Availability
100mg $750.00 in stock
250mg $1400.00 in stock
1g $2600.00 in stock
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Fields of Application :
AX15836 is a highly potent and selective ERK5 inhibitor.
CAS Number: N/A
Purity:

>98%

Molecular Weight: 648.78
Molecular Formula: C32H40N8O5S
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: AX15836; AX 15836; AX-15836
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
Potent and selective ERK5 inhibitor (IC50 = 8 nM). Exhibits >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Also exhibits selectivity over bromodomain BRD4 (Kd = 3,600 nM). Increases vomocytosis in human macrophages in vitro, as well as in an in vivo zebrafish model of cryptococcal disease, reducing spread of infection.
References:
O=C1C2=CC=CC=C2N(S(=O)(C)=O)C3=NC(NC4=CC=C(C(N5CCC(N6CCN(C)CC6)CC5)=O)C=C4OCC)=NC=C3N1C
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