AZD6482

  Cat. No.:  DC8004  
AZD6482
Chemical Structure
1173900-33-8
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More than 5000 active chemicals with high quality for research!
Field of application
AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ.
Cas No.: 1173900-33-8
Chemical Name: (-)-2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
Synonyms: AZD-6482, AZD 6482
SMILES: O=C1N2C(C([C@H](NC3=CC=CC=C3C(O)=O)C)=CC(C)=C2)=NC(N4CCOCC4)=C1
Formula: C22H24N4O4
M.Wt: 408.45
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ.AZD6482 is a PI3Kβ inhibitor (IC50=0.021μM) used in antithrombotic therapy. AZD6482 targets a process that is critical to pathological thrombus formation without interfering with normal haemostasis, which avoids the drawbacks of the existing anti-thrombotic therapy. AZD6482 inhibits PI3Kβ/α/γ/δwith IC50 of 0.021, 1.4, 1.2, 0.08μM, respectively. It washed platelet aggregation with concentration at 6 nM. For the detailed information of AZD6482, the solubility of AZD6482 in water, the solubility of AZD6482 in DMSO, the solubility of AZD6482 in PBS buffer, the animal experiment (test) of AZD6482, the cell expriment (test) of AZD6482, the in vivo, in vitro and clinical trial test of AZD6482, the EC50, IC50,and affinity,of AZD6482, Please contact DC Chemicals.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC8004 AZD6482 AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ.