Apostatin-1 (Apt-1)

  Cat. No.:  DC39045   Featured
Apostatin-1 (Apt-1)
Chemical Structure
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Field of application
Apostatin-1 (Apt-1) is a novel TRADD inhibitor.Apostatin-1 inhibits RIPK1-dependent apoptosis (RDA) with IC50 of 1.28 μM and shows no significant off-target activity on 97 kinases in KINOME scan profiling.Inhibition of TRADD by Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin. Treatment with Apt-1 restored proteostasis and inhibited cell death in a mouse model of proteinopathy induced by mutant tau(P301S).
Cas No.:
Chemical Name: Apostatin-1
Synonyms: Apostatin-1;Apostatin-1;Apostatin-1;APT1;APT 1;APT-1
SMILES: C1(SC(C2C=CC=CC=2)C(NC2CCCCCC2)=O)=NCCN1C
Formula: C19H27N3Os
M.Wt: 345.502
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: Daichao Xu, Heng Zhao, Minzhi Jin, et al.Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.Nature.Published: 23 September 2020
Description:
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MSDS
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