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BMN-673 8R,9S
DC8452  (CAS:1207456-00-5)
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Fields of Application :
BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673. BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM(PARP1). It does not inhibit PARG and is highly sensitive to PTEN mutation.
CAS Number: 1207456-00-5
Purity:

>95%ee>92%

Molecular Weight: 380.35
Molecular Formula: C19H14F2N6O
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: Talazoparib (8R,9S); (8R,9S)-BMN-673; BMN673 (8R,9S); BMN 673 (8R,9S)
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development. For the detailed information of BMN-673 8R,9S, the solubility of BMN-673 8R,9S in water, the solubility of BMN-673 8R,9S in DMSO, the solubility of BMN-673 8R,9S in PBS buffer, the animal experiment (test) of BMN-673 8R,9S, the cell expriment (test) of BMN-673 8R,9S, the in vivo, in vitro and clinical trial test of BMN-673 8R,9S, the EC50, IC50,and affinity,of BMN-673 8R,9S, For the detailed information of BMN-673 8R,9S, the solubility of BMN-673 8R,9S in water, the solubility of BMN-673 8R,9S in DMSO, the solubility of BMN-673 8R,9S in PBS buffer, the animal experiment (test) of BMN-673 8R,9S, the cell expriment (test) of BMN-673 8R,9S, the in vivo, in vitro and clinical trial test of BMN-673 8R,9S, the EC50, IC50,and affinity,of BMN-673 8R,9S, Please contact DC Chemicals.
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