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BMS-1166
DC12058  (CAS:1818314-88-3)
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25mg USD 950 in stock
50mg USD 1500 in stock
100mg USD 2300 in stock
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Fields of Application :
BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM.
CAS Number: 1818314-88-3
Purity:

>98%

Molecular Weight: 641.11
Molecular Formula: C36H33ClN2O7
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: BMS1166,BMS 1166
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
In Vitro BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1.
References:
O=C(O)[C@@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[C@H](O)C1
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