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B I09
DC12114  (CAS:1607803-67-7)
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Fields of Application :
B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.
CAS Number: 1607803-67-7

Molecular Weight: 303.31
Molecular Formula: C16H17NO5
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
In Vitro B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM[1]. Treatment of CLL cells with this inhibitor (B I09) mimick XBP-1 deficiency, including upregulation of IRE-1 expression and compromised BCR signaling. B I09 is highly effective in inhibiting splicing of XBP1 mRNA in human WaC3 cells and the expression of XBP-1s in LPS stimulated B cells. In Vivo B I09 has a halflife of approximately 1.5 hours and reaches its peak concentration of approximately 39 M in mouse plasma serum 15 minutes after administration. Administration of B I09 to CLL tumor-bearing mice suppress leukemic progression by inducing apoptosis and do not cause systemic toxicity.
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