B I09

  Cat. No.:  DC12114  
B I09
Chemical Structure
1607803-67-7
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More than 5000 active chemicals with high quality for research!
Field of application
B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.
Cas No.: 1607803-67-7
Chemical Name:
Synonyms:
SMILES: OC1=CC=C(C2=C(CNCC2)C3=O)C(O3)=C1C4OCCCO4
Formula: C16H17NO5
M.Wt: 303.31
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: In Vitro B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM[1]. Treatment of CLL cells with this inhibitor (B I09) mimick XBP-1 deficiency, including upregulation of IRE-1 expression and compromised BCR signaling. B I09 is highly effective in inhibiting splicing of XBP1 mRNA in human WaC3 cells and the expression of XBP-1s in LPS stimulated B cells. In Vivo B I09 has a halflife of approximately 1.5 hours and reaches its peak concentration of approximately 39 μM in mouse plasma serum 15 minutes after administration. Administration of B I09 to CLL tumor-bearing mice suppress leukemic progression by inducing apoptosis and do not cause systemic toxicity.
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In Vitro:
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Animal Administration:
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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