LOGIN IN
REGISTER
PRODUCTS
More than 5000 active chemicals with high quality for research!

Email sales@dcchemicals.com

        order@dcchemicals.com

        info@dcchemicals.com


Phone:  +86-21-58447131

Fax   +86-21-61642470

B I09
DC12114  (CAS:1607803-67-7)
(Based on popularity)
Size Price Availability
100mg USD get quote in stock
250mg USD get quote in stock
1g USD get quote in stock
We match the best price and quality on market.
 
 
Email: order@dcchemicals.com
Tel: +86-21-58447131
Fax:+86-21-61642470
Fields of Application :
B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.
CAS Number: 1607803-67-7
Purity:

Molecular Weight: 303.31
Molecular Formula: C16H17NO5
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms:
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
In Vitro B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM[1]. Treatment of CLL cells with this inhibitor (B I09) mimick XBP-1 deficiency, including upregulation of IRE-1 expression and compromised BCR signaling. B I09 is highly effective in inhibiting splicing of XBP1 mRNA in human WaC3 cells and the expression of XBP-1s in LPS stimulated B cells. In Vivo B I09 has a halflife of approximately 1.5 hours and reaches its peak concentration of approximately 39 M in mouse plasma serum 15 minutes after administration. Administration of B I09 to CLL tumor-bearing mice suppress leukemic progression by inducing apoptosis and do not cause systemic toxicity.
References:
OC1=CC=C(C2=C(CNCC2)C3=O)C(O3)=C1C4OCCCO4
About us Products Services ordering sitemap
Phone: +86-21-58447131Fax: +86-21-61642470
ADDRoom 610, Building 15, Jinxiang Rd 201, Pudong,Shanghai, China
CopyRight-2010-2013 DC Chemicals All Rights Reserved