NIK inhibitor 4f

  Cat. No.:  DC10927  
NIK inhibitor 4f
Chemical Structure
1660114-31-7
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Field of application
NIK inhibitor 4f is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 0.23 nM, shows an IC50 of 34 nM in NF-κB reporter assays.
Cas No.: 1660114-31-7
Chemical Name: (R)-6-(3-((3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamid
Synonyms:
SMILES: C(C(N)=O)1=NC(C2=CC=CC(C#C[C@](O)3CCN(C)C3=O)=C2)=CC(OC)=C1
Formula: C20H19N3O4
M.Wt: 365.389
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: NIK inhibitor 4f is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 0.23 nM, shows an IC50 of 34 nM in NF-κB reporter assays; displays excellent kinome selectivity, only inhibits only KHS1 > 50% in a 228 panel of kinases tested at 0.1 uM (>400-fold NIK Ki); demonstrates suitable properties for advanced ADME and pharmacology experiments; selectively inhibits nuclear translocation of p52 (RelB) with IC50 of 70 nM, without effect on nuclear translocation of canonical NF-κB marker RelA (>20 uM); inhibits BAFF induced B-cell survival in vitro and splenic marginal zone B-cells in a dose/concentrationdependent manner.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC10927 NIK inhibitor 4f NIK inhibitor 4f is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 0.23 nM, shows an IC50 of 34 nM in NF-κB reporter assays.
DC11180 Amgen 16 Amgen16 is a highly potent inhibitor of NF-κB inducing Kinase (NIK), example 294 in patent WO 2009158011 A1..
DC11181 AM-0561 AM-0561 (AM0561) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 0.3 nM..
DC11182 AM-0216 AM-0216 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NFkB activity is NIK-dependent.