STING inhibitor C-178

  Cat. No.:  DC10959   Featured
STING inhibitor C-178
Chemical Structure
329198-87-0
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Field of application
STING inhibitor C-178 is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING; covalently binds to Cys91, directly targets mouse STING (mmSTING) but not human STING (hsSTING).
Cas No.: 329198-87-0
Chemical Name: N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide
Synonyms:
SMILES: O1C([N+]([O-])=O)=CC=C1C(NC1C=C2C(=CC=1)C1=CC=CC=C1O2)=O
Formula: C17H10N2O5
M.Wt: 322.276
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: STING inhibitor C-178 is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING; covalently binds to Cys91, directly targets mouse STING (mmSTING) but not human STING (hsSTING).
In Vivo:
In Vitro:
References:
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC10959 STING inhibitor C-178 STING inhibitor C-178 is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING; covalently binds to Cys91, directly targets mouse STING (mmSTING) but not human STING (hsSTING).
DC10960 STING inhibitor C-176 STING inhibitor C-178 is a covalent, in vivo-active, small-molecule inhibitor of STING
DC11451 STING agonist compound 3 STING agonist-3 is a novel STING agonist with even better activity than cGAMP.
DC10908 ML RR-S2 CDA ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds and is an activator of stimulator of interferon genes (STING).
DC10876 H-151 H-151(H151) is a novel STING (stimulator of interferon genes) antagonist.
DC12321 STING agonist-1(compound 3)trihydrochloride diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist.
DC12367 2'3'-cGAMP 2'3'-cGAMP has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA.