JPI-289

  Cat. No.:  DC11080  
JPI-289
Chemical Structure
1449233-60-6
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More than 5000 active chemicals with high quality for research!
Field of application
JPI-289 (JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.
Cas No.: 1449233-60-6
Chemical Name: 10-ethoxy-8-(morpholinomethyl)-2,3,4,6-tetrahydrobenzo[h][1,6]naphthyridin-5(1H)-one dihydrochloride dihydrate
Synonyms: JPI289
SMILES: N1C2=C(C(=O)NC3=CC(CN4CCOCC4)=CC(OCC)=C32)CCC1.[H]Cl.[H]Cl.[H]O[H].[H]O[H]
Formula: C19H31Cl2N3O5
M.Wt: 452.373
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: JPI-289 (JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke.
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COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC11075 Amelparib
DC11080 JPI-289 JPI-289 (JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.