ICSN3250

  Cat. No.:  DC11150  
ICSN3250
Chemical Structure
1561902-73-5
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More than 5000 active chemicals with high quality for research!
Field of application
ICSN3250 (ICSN-3250) is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors.
Cas No.: 1561902-73-5
Chemical Name: 5,5'-(1-(3-(azacyclotridecan-1-yl)propyl)-1H-pyrrole-3,4-diyl)bis(3-nitrobenzene-1,2-diol)
Synonyms: ICSN-3250
SMILES: N(CCCN1CCCCCCCCCCCC1)1C=C(C2C=C(O)C(O)=C([N+]([O-])=O)C=2)C(C2C=C(O)C(O)=C([N+]([O-])=O)C=2)=C1
Formula: C31H40N4O8
M.Wt: 596.681
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: ICSN3250 (ICSN-3250) is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors; ICSN3250 is not a kinase inhibitor of mTOR, competes with and displaces phosphatidic acid from the FRB domain in mTOR, thus preventing mTOR activation and leading to cytotoxicity; displays no inhibitory capacity towards PI3Kα, β, γ, or δ; inhibits mTORC1 by following an unprecedented mechanism that involved its competition with PA at the FRB domain of mTOR to overcome the TSC negative regulation of mTORC1; ICSN3250 specifically targets cancer cells both in vitro and ex vivo.
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MSDS
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LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC5088 WYE125132 WYE125132 is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor
DC11816 RapaLink-1 RapaLink-1 is a third-generation mTOR inhibitor that overcomes resistance to existing first- and second-generation inhibitors.
DC7210 LY-303511 LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K.
DC3101 Ku-0063794 KU-0063794 is a potent and highly specific mTOR inhibitor for both mTORC1 and mTORC2 with IC50 ~10 nM.
DC11150 ICSN3250 ICSN3250 (ICSN-3250) is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors.
DC11151 ICSN3250 hydrochloride ICSN3250 (ICSN-3250) hydrochloride is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors.
DC11866 AZD 3147 A potent, selective dual mTORC1 and mTORC2 inhibitor with enzyme IC50 of 1.5 nM.