AKS1-IN-19

  Cat. No.:  DC11610  
AKS1-IN-19
Chemical Structure
2089638-10-6
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More than 5000 active chemicals with high quality for research!
Field of application
A novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3.
Cas No.: 2089638-10-6
Chemical Name: (R)-2-(6-(4-(1-hydroxypropan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-6-isopropoxyisoindolin-1-one
Synonyms: AKS1 inhibitor 19
SMILES: C(=O)1C2=C(C=CC(OC(C)C)=C2)CN1C1=NC(C2N([C@@H](C)CO)C=NN=2)=CC=C1
Formula: C21H23N5O3
M.Wt: 393.447
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: A novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3; displays good kinase selectivity with only 32 kinases having less than 30 fold selectivity in a panel of 356 kinases; inhibits phospho-JNK with pEC50 of 8.2 in cellular assays; displayed robust MAP3K pathway inhibition and reduction of infarct size in an isolated perfused heart model of cardiac injury.
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Animal Administration:
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC11036 TCASK10 TCASK10 is a potent, highly specific inhibitor of ASK1 with IC50 of 14 nM, 30-fold selectivity over ASK2 (IC50=510 nM) and no activity against MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf.
DC9555 Cot inhibitor-2 Cot inhibitor-2 is a COT/Tpl2 inhibitor.
DC11558 DLK-IN-14 A potent, selective, CNS penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of 3 nM.
DC11610 AKS1-IN-19 A novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3.
DC11622 MAP3K14-IN-173 A novel potent MAP3K14 kinase inhibitor with IC50 of 1.8 nM (NIK autophosphorylation).