BI 885578

  Cat. No.:  DC11760  
BI 885578
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
BI 885578 (BI-885578, BI885578) is a potent,selective, ATP-competitive IGF1R/InsR tyrosine kinase inhibitor with Kd of 9 nM/12 nM, IC50 of 1 nM/1 nM, respectively.
Cas No.:
Chemical Name: (S)-N-(1-(2-(4-(2-methoxyethyl)piperazin-1-yl)ethyl)-1H-pyrazol-3-yl)-2,5-dimethyl-1-phenyl-4,5-dihydro-2H-pyrazolo[4,3-f]quinazolin-7-amine
Synonyms: BI-885578;BI885578
SMILES: N1=C2C(C3=C(C4=CC=CC=C4)N(C)N=C3C[C@H]2C)=CN=C1NC1C=CN(CCN2CCN(CCOC)CC2)N=1
Formula: C29H37N9O
M.Wt: 527.677
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: BI 885578 (BI-885578, BI885578) is a potent,selective, ATP-competitive IGF1R/InsR tyrosine kinase inhibitor with Kd of 9 nM/12 nM, IC50 of 1 nM/1 nM, respectively; inhibits IGF1R/InsR cellular autophosphorylation with IC50 of 5 nM/5 nM respectively; significantly reduces the growth of xenografted human GEO and CL-14 colon carcinoma tumors, displays an acceptable tolerability profile in mice.
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Kinase Assay:
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Animal Administration:
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC28921 I-OMe-Tyrphostin AG 538 I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 µM.
DC2069 IGF-1R inhibitor GS1904529A GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, respectively.
DC11760 BI 885578 BI 885578 (BI-885578, BI885578) is a potent,selective, ATP-competitive IGF1R/InsR tyrosine kinase inhibitor with Kd of 9 nM/12 nM, IC50 of 1 nM/1 nM, respectively.
DC10112 AZD9362 AZD-9362 is dual IGF-IR/InsR inhibitor.