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WRG-28
DC22073  (CAS:1913291-02-7)
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Fields of Application :
WRG-28 (DDR2 inhibitor WRG-28) is a potent, selective, allosteric inhibitor of discoidin domain receptor 2 (DDR2) with binding IC50 of 230 nM.
CAS Number: 1913291-02-7
Purity:

Molecular Weight: 410.444
Molecular Formula: C21H18N2O5S
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: WRG-28|DDR2 inhibitor WRG-28;WRG28
Chemical Name: N-ethyl-4-(((3-oxo-3H-phenoxazin-7-yl)oxy)methyl)benzenesulfonamide
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
WRG-28 (DDR2 inhibitor WRG-28) is a potent, selective, allosteric inhibitor of discoidin domain receptor 2 (DDR2) with binding IC50 of 230 nM; blunted collagen I-mediated DDR2 tyrosine phosphorylation, ERK activation, and SNAIL1 protein stabilization (IC50=286 nM) in HEK293 cells expressing DDR2, without effect on normal mammary epithelial MCF10A cells; displays no activity against collagen I-induced tyrosine phosphorylation of the related DDR1 RTK in HEK293 cells; WRG-28 inhibits DDR2-collagen interaction in an allosteric manner, inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs.
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