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DMX-5804
DC22077  (CAS:)
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Fields of Application :
DMX-5804 (DMX5804) is a potent,selective small-molecule inhibitor of MAP4K4 with IC50 of 3 nM.
CAS Number:
Purity:

Molecular Weight: 361.401
Molecular Formula: C21H19N3O3
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: DMX-5804|DMX5804;DMX 5804
Chemical Name: 5-(4-(2-methoxyethoxy)phenyl)-7-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
DMX-5804 (DMX5804) is a potent,selective small-molecule inhibitor of MAP4K4 with IC50 of 3 nM; displays >100-fold selectivity over GCK/MAP4K2, GLK/MAP4K3, KHS/MAP4K5 and VEGFR; rescues cell survival, mitochondrial function, and calcium cycling in hiPSC-CMs (human induced-pluripotent-stem-cell-derived cardiomyocytes), protects hiPSC-CMs with EC50 of 500 nM for cell death induced by 400 uM H2O2; reduces infarct size and ischemia-reperfusion injury in mice in mice.
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