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DS-437
DC22082  (CAS:1674364-87-4)
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Fields of Application :
DS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7 with IC50 of 6.0 uM for both, DS-437 is inactive against 29 other human protein-, DNA-, and RNA-methyltransferases.
CAS Number: 1674364-87-4
Purity:

Molecular Weight: 397.454
Molecular Formula: C15H23N7O4S
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: DS-437|DS437;DS 437
Chemical Name: 1-[2-[[(2S,3R,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]ethyl]-3-ethylurea
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
DS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7 with IC50 of 6.0 uM for both, DS-437 is inactive against 29 other human protein-, DNA-, and RNA-methyltransferases; inhibits methylation of full-length histone 4 by PRMT5-MEP50 with an IC50 of 37 1.2 M in a biochemical assay; inhibits symmetrical dimethylation of PRMT5 substrates in cells.
References:
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