DLin-KC2-DMA

  Cat. No.:  DC12381   Featured
DLin-KC2-DMA
Chemical Structure
1190197-97-7
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Field of application
DLin-KC2-DMA is 100-fold and 1000-fold more potent, respectively, in silencing of a hepatic gene (Factor VII) in comparison to the previous generation lipid DLin-DMA.
Cas No.: 1190197-97-7
Chemical Name: 2,2-dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane
Synonyms:
SMILES: CN(CCC1OC(CCCCCCCC/C=C\C/C=C\CCCCC)(CCCCCCCC/C=C\C/C=C\CCCCC)OC1)C
Formula: C43H79NO2
M.Wt: 641.61
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: DLin-KC2-DMA is useful cationic lipid for siRNA delivery. DLin-KC2-DMA (2,2-dilinoleyl-4-(2-dimethylaminoethyl)-[1,3]-dioxolane), and DLin-MC3-DMA, which are 100-fold and 1000-fold more potent, respectively, in silencing of a hepatic gene (Factor VII) in comparison to the previous generation lipid DLin-DMA (1,2-dilinoleyloxy-N,N-dimethyl-3-aminopropane).The ED50 (median effective dose) for LNP containing DLin-MC3-DMA to silence Factor VII in mice and TTR in non-human primates was 0.005 mg/kg and 0.03 mg/kg, respectively.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC31024 Lipid 5 Lipid 5 is a novel ionizable lipid for RNA delivery.
DC31004 ATX-087 ATX-087 is a novel ionizable cationic lipids for RNA delivery.
DC31003 ATX-084 ATX-084 is an ionizable cationic lipids for RNA or Gene delivery.
DC31002 ATX-083 ATX-083 is an ionizable cationic lipids for RNA delivery.
DC31001 ATX-081 ATX-081 is an ionizable cationic lipids for RNA or Gene delivery.
DC10800 DLin-MC3-DMA D-Lin-MC3-DMA(MC3) is the most potent cationic lipid that has been synthesized for Lipid nanoparticles (LNPs) to deliver the siRNA.
DC12381 DLin-KC2-DMA DLin-KC2-DMA is 100-fold and 1000-fold more potent, respectively, in silencing of a hepatic gene (Factor VII) in comparison to the previous generation lipid DLin-DMA.
DC12145 DLinDMA DLinDMA is a key lipid component of stable nucleic acid lipid particles as a benchmark.