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Dasatinib monohydrate
DC3140  (CAS:863127-77-9)
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Fields of Application :
Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases.
CAS Number: 863127-77-9
Purity:

>98%

Molecular Weight: 506.02
Molecular Formula: C22H28ClN7O3S
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms:
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
Description of Dasatinib: Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity For the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic Forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) For the detailed information about the solubility of Dasatinib monohydrate in water, the solubility of Dasatinib monohydrate in DMSO, the solubility of Dasatinib monohydrate in PBS buffer, the animal experimenttest of Dasatinib monohydrate,the in vivo,in vitro and clinical trial test of Dasatinib monohydrate,the cell experimenttest of Dasatinib monohydrate,the IC50, EC50 and Affinity of Dasatinib monohydrate, please contact DC Chemicals.
References:
O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCO)CC3)=C2)S1)NC4=C(C)C=CC=C4Cl.[H]O[H]
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