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Disodium (R)-2-Hydroxyglutarate
DC8385  (CAS:103404-90-6)
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Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of -ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.
CAS Number: 103404-90-6
Purity:

>98%

Molecular Weight: 192.08
Molecular Formula: C5H6Na2O5
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms:
Chemical Name: sodium (R)-2-hydroxypentanedioate
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
In U-87MG cells, (R)-2-Hydroxyglutarate acts as weak antagonists of -KG to inhibit -KG-dependent histone demethylases and increases dimethylation on both H3K9 and H3K79. Besides, (R)-2-Hydroxyglutarate inhibits ATP synthase and mTOR signaling, and thus causes growth arrest and tumor cell killing. For the detailed information of Disodium (R)-2-Hydroxyglutarate, the solubility of Disodium (R)-2-Hydroxyglutarate in water, the solubility of Disodium (R)-2-Hydroxyglutarate in DMSO, the solubility of Disodium (R)-2-Hydroxyglutarate in PBS buffer, the animal experiment (test) of Disodium (R)-2-Hydroxyglutarate, the cell expriment (test) of Disodium (R)-2-Hydroxyglutarate, the in vivo, in vitro and clinical trial test of Disodium (R)-2-Hydroxyglutarate, the EC50, IC50,and affinity,of Disodium (R)-2-Hydroxyglutarate, For the detailed information of Disodium (R)-2-Hydroxyglutarate, the solubility of Disodium (R)-2-Hydroxyglutarate in water, the solubility of Disodium (R)-2-Hydroxyglutarate in DMSO, the solubility of Disodium (R)-2-Hydroxyglutarate in PBS buffer, the animal experiment (test) of Disodium (R)-2-Hydroxyglutarate, the cell expriment (test) of Disodium (R)-2-Hydroxyglutarate, the in vivo, in vitro and clinical trial test of Disodium (R)-2-Hydroxyglutarate, the EC50, IC50,and affinity,of Disodium (R)-2-Hydroxyglutarate, Please contact DC Chemicals.
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