E6005

  Cat. No.:  DC10141   Featured
E6005
Chemical Structure
947620-48-6
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More than 5000 active chemicals with high quality for research!
Field of application
E6005 potently and selectively inhibited human PDE4 activity with an IC50 of 2.8 nM and suppressed the production of various cytokines from human lymphocytes and monocytes with IC50 values ranging from 0.49 to 3.1 nM.
Cas No.: 947620-48-6
Chemical Name: (methyl 4-[({3-[6,7-dimethoxy-2(methylamino)quinazolin-4yl]phenyl}amino)carbonyl]benzoate
Synonyms: E 6005,E-6005
SMILES: C1=C(OC)C(OC)=CC2N=C(NC)N=C(C3=CC(NC(C4=CC=C(C(OC)=O)C=C4)=O)=CC=C3)C1=2
Formula: C26H24N4O5
M.Wt: 472.49
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: E6005 potently and selectively inhibited human PDE4 activity with an IC50 of 2.8 nM and suppressed the production of various cytokines from human lymphocytes and monocytes with IC50 values ranging from 0.49 to 3.1 nM. In mice models, the topical application of E6005 produced an immediate antipruritic effect as well as an anti-inflammatory effect with reduced expression of cytokines/adhesion molecules. On the basis of these observed effects, topical E6005 ameliorated the appearance of atopic dermatitis-like skin lesions in two types of AD models, hapten- and mite-elicited models, exhibiting inhibitory effects comparable to that of tacrolimus. The use of 14Clabeled E6005 showed rapid clearance from the blood and low distribution to the brain, contributing to the low emetic potential of this compound. E6005 is a novel therapeutic agent with antipruritic activity for the treatment of AD.
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COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC10141 E6005 E6005 potently and selectively inhibited human PDE4 activity with an IC50 of 2.8 nM and suppressed the production of various cytokines from human lymphocytes and monocytes with IC50 values ranging from 0.49 to 3.1 nM.
DC7815 Crisaborole(AN-2728) AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.