Cat. No.:  DC50002   Featured
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
EDP-305 is a novel and potent farnesoid X receptor (FXR) agonist, with no/minimal cross-reactivity to TGR5 or other nuclear receptors.
Cas No.: 1933507-63-1
Chemical Name: EDP-305
Synonyms: EDP-305;EDP305;EDP 305
SMILES: [C@H]1(C[C@]2([H])[C@@H](CC)[C@@H](O)[C@]3([H])[C@]4([H])CC[C@H]([C@@H](CCNC(=O)NS(=O)(=O)C5=CC=C(C(C)(C)C)C=C5)C)[C@@]4(C)CC[C@]3([H])[C@@]2(C)CC1)O
Formula: C36H58N2O5S
M.Wt: 630.92
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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Kinase Assay:
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Animal Administration:
Cat. No. Product name Field of application
DC50028 Laninamivir Octanoate Laninamivir (L174000) prodrug; a novel long-acting neuraminidase inhibitor.
DC50027 ENMD-2076 L-(+)-Tartaric acid ENMD-2076 Tartrate is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively.
DC50026 GSK-114 GSK-114 is a potent and selective selective TNNI3K inhibitor (TNNI3 IC50 = 25nM; B-RafV600E IC50 = 1000 nM). GSK-114 displays significant bias (40-fold) for TNNI3K over B-Raf, exceptional broad spectrum kinase selectivity, and adequate oral exposure to enable its use in cellular and in vivo studies. Cardiac troponin I-interacting kinase (TNNI3K or CARK) is a member of the tyrosine-like kinase family that is selectively expressed in heart tissue. TNNI3K has been linked to the progression of dilated cardiomyopathy, cardiac hypertrophy, and ischemia/reperfusion injury using models that employ Tnni3k overexpressing or Tnni3k knockout animals.
DC50025 Deruxtecan Deruxtecan, a topoisomerase I inhibitor, is an exatecan derivative (DX-8951 derivative) with a cleavable pepetide linker and a maleimide group. The maleimide group in Deruxtecan can react with antibody to form antibody-drug conguates (ADC) such as Trastuzumab deruxtecan (DS-8201a), which is a HER2-targeting antibody–drug conjugate.
DC50023 Compound 5i Compound 5i is a novel and brain-penetrant O-GlcNAcase inhibitor with IC50 of 46 nM.
DC50022 ACH-000143 ACH-000143 is a novel potent melatonin receptor agonist with EC50 of 0.06 nM/0.32 nM against MT1/MT2. ACH-000143 leads to a reduction in body weight gain similar to dapagliflozin with superior results on hepatic steatosis and triglyceride levels in high-fat diet rats.
DC50021 JMX0493 JMX0493 is a potent inhibitor of human adenoviruses (HAdVs) with IC50 of 0.78 μM and displays high selectivity index (SI>100) and 2.5-fold virus yield reduction compared to niclosamide. JMX0493 targets the HAdV entry pathway that prevents viral particle disassembly and subsequent release from the endosome.
DC50020 LOXO-305 LOXO-305 is an investigational, novel, selective non-covalent Bruton’s tyrosine kinase (BTK) inhibitor. LOXO-305 was designed to reversibly bind BTK, preserve activity in the presence of the acquired resistance, and avoid off-target kinases that have complicated the development of both covalent and investigational non-covalent BTK inhibitors.LOXO-305 is a highly selective, non-covalent BTKi that inhibits both wild type (WT) and C481-mutated BTK with equal low nM potency was developed.
DC50015 VBIT-4 VBIT-4 is an inhibitor of VDAC1, the outer mitochondrial membrane protein known as voltage-dependent anion channel 1. VBIT-4 inhibits VDAC1 oligomerization, apoptosis, and mitochondrial dysfunction.
DC50013 BC1618 BC1618 is a novel Fbxo48 inhibitor and prevent pAmpkα degradation with MEC (minimal efficacious concentration) of 0.6 μM.