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ESI-09
DC8443  (CAS:263707-16-0)
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100mg USD 350 In stock
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Fields of Application :
ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 M and 1.4 M for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.
CAS Number: 263707-16-0
Purity:

>98%

Molecular Weight: 330.77
Molecular Formula: C16H15ClN4O2
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: ESI-09,ESI 09,ESI09
Chemical Name: (E)-3-(5-tert-butylisoxazol-3-yl)-2-(2-(3-chlorophenyl)hydrazono)-3-oxopropanenitrile
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
ESI-09, a novel non-cyclic nucleotide EPAC antagonist, that is capable of specifically blocking intracellular EPAC-mediated Rap1 activation and Akt phosphorylation, as well as EPAC-mediated insulin secretion in pancreatic cells. On the other hand, ESI-09 fails to suppress epidermal growth factor (EGF)-induced phosphorylation of Akt in AsPC1 cells. In pancreatic cancer cells, ESI-09 inhibits cells migration and invasion through decreasing 007-AM-induced cell adhesion dose-dependently. ESI-09 significantly reduces intracellular and total bacterial counts in human umbilical vein endothelial cells. ESI-09 effectively antagonizes Schwann cells (SC) differentiation induced by CPT-cAMP as well as the formation of myelin. In SC-neuron cultures, ESI-09 dramatically reduces the number of O1 positive and MBP positive SCs without compromising the health of the neurons or the SCs themselves. ESI-09 (10 mg/kg/d, i.p.), via pharmacological inhibition of EPAC1, protects WT C57BL/6 mice from fatal SFG rickettsiosis. For the detailed information of ESI-09, the solubility of ESI-09 in water, the solubility of ESI-09 in DMSO, the solubility of ESI-09 in PBS buffer, the animal experiment (test) of ESI-09, the cell expriment (test) of ESI-09, the in vivo, in vitro and clinical trial test of ESI-09, the EC50, IC50,and affinity,of ESI-09, For the detailed information of ESI-09, the solubility of ESI-09 in water, the solubility of ESI-09 in DMSO, the solubility of ESI-09 in PBS buffer, the animal experiment (test) of ESI-09, the cell expriment (test) of ESI-09, the in vivo, in vitro and clinical trial test of ESI-09, the EC50, IC50,and affinity,of ESI-09, Please contact DC Chemicals.
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