More than 5000 active chemicals with high quality for research!

Email sales@dcchemicals.com



Phone:  +86-21-58447131

Fax   +86-21-61642470

DC8870  (CAS:22368-21-4)
(Based on popularity)
Size Price Availability
100mg USD 450 in stock
250mg USD 700 in stock
1g USD 1500 in stock
We match the best price and quality on market.
Email: order@dcchemicals.com
Tel: +86-21-58447131
Fields of Application :
Eupatilin is a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells.
CAS Number: 22368-21-4


Molecular Weight: 344.31
Molecular Formula: C18H16O7
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: NSC 122413
Chemical Name:
Storage: 4 Degree for 1 year, -20 degree for more than 2 years
Note: Products for research use only, not for human use
Eupatilin inhibited the growth of MCF10A-ras cells in a concentration-dependent and time-related manner. To explore whether the anti-proliferative effects of eupatilin could be mediated through modulation of the cell cycle in MCF10A-ras, DNA contents were analyzed by the flow cytometry. Eupatilin inhibited the expression of cyclin D1, cyclin B1, Cdk2 and Cdc2 that are key regulators of the cell cycle. In addition, eupatilin treatment led to elevated expression of p53 and p27Kip1 that act as Cdk inhibitors. It has been known that the Ras-signaling pathway plays integral roles in the induction of cyclin D1. Eupatilin inhibited the activation of ERK1/2 as well as expression of Raf-1 and Ras in MCF10A-ras cells. Thus, the inhibitory effect of eupatilin on cyclin D1 expression appears to be mediated by targeting the Raf/MEK/ERK signaling cascades. Eupatilin did not change activation of Akt, an important component of cell-survival pathways. In conclusion, the anti-proliferative effect of eupatilin in MCF10A-ras cells is associated with its blockade of cell cycle progression which appears to be attributable in part to inhibition of ERK1/2 activation. For the detailed information of Eupatilin, the solubility of Eupatilin in water, the solubility of Eupatilin in DMSO, the solubility of Eupatilin in PBS buffer, the animal experimenttest (test) of Eupatilin, the cell expriment (test) of Eupatilin, the in vivo, in vitro and clinical trial test of Eupatilin, the EC50, IC50,and Affinity of Eupatilin,, please contact DC Chemicals.
About us Products Services ordering sitemap
Phone: +86-21-58447131Fax: +86-21-61642470
ADDRoom 610, Building 15, Jinxiang Rd 201, Pudong,Shanghai, China
CopyRight-2010-2013 DC Chemicals All Rights Reserved