Cat. No.:  DC12495   Featured
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
GNE-6640 is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM).
Cas No.: 2009273-67-8
Chemical Name:
Synonyms: GNE-6640,GNE 6640,GNE6640,2009273-67-8
Formula: C20H18N4O
M.Wt: 330.14
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: GNE-6640 is a novel selective USP7 inhibitor, inducing tumor cell death. GNE-6640 enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors.
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Cat. No. Product name Field of application
DC11506 USP25 and 28 inhibitor AZ-1 USP25 and 28 inhibitor AZ-1 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.7/0.6 uM, respectively; shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.)
DC8319 Spautin 1 Spautin 1 is an inhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes.
DC10001 NSC632839 NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2, USP7, and SENP2 with EC50s of 45±4 μM, 37±1 μM, and 9.8±1.8 μM, respectively.
DC10091 ML364 ML364 is an USP2 inhibitor.xtracted from patent WO 2016134026 A1, compound example 10G.
DC7468 ML-323 ML323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively.
DC12049 GSK2643943A GSK2643943A is a potent USP20 inhibitor with IC50 = 160 nM.
DC12495 GNE-6640 GNE-6640 is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM).
DC10838 F1063-0967 F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.