GNE-6640

  Cat. No.:  DC12495   Featured
GNE-6640
Chemical Structure
2009273-67-8
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Field of application
GNE-6640 is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM).
Cas No.: 2009273-67-8
Chemical Name:
Synonyms: GNE-6640,GNE 6640,GNE6640,2009273-67-8
SMILES: OC1=CC=C(C2=C(CC)C(C3=CC4=C(NN=C4)C=C3)=CN=C2N)C=C1
Formula: C20H18N4O
M.Wt: 330.14
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: GNE-6640 is a novel selective USP7 inhibitor, inducing tumor cell death. GNE-6640 enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors.
In Vivo:
In Vitro:
References:
Kinase Assay:
Cell Assay:
Animal Administration:
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC10001 NSC632839 NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2, USP7, and SENP2 with EC50s of 45±4 μM, 37±1 μM, and 9.8±1.8 μM, respectively.
DC10091 ML364 ML364 is an USP2 inhibitor.xtracted from patent WO 2016134026 A1, compound example 10G.
DC7468 ML-323 ML323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively.
DC12049 GSK2643943A GSK2643943A is a potent USP20 inhibitor with IC50 = 160 nM.
DC12495 GNE-6640 GNE-6640 is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM).
DC10838 F1063-0967 F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.