LOGIN IN
REGISTER
PRODUCTS
More than 5000 active chemicals with high quality for research!

Email: sales@dcchemicals.com

        order@dcchemicals.com

        info@dcchemicals.com


Phone:  +86-21-58447131

Fax:   +86-21-61642470

GSK2830371
DC8422  (CAS:1404456-53-6)
(Based on popularity)
Size Price Availability
100mg USD 450 In stock
250mg USD 800 In stock
1g USD 1700 In stock
We match the best price and quality on market.
 
 
Email: order@dcchemicals.com
Tel: +86-21-58447131
Fax:+86-21-61642470
Fields of Application :
GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.
CAS Number: 1404456-53-6
Purity:

>98%

Molecular Weight: 461.02
Molecular Formula: C23H29ClN4O2S
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
Synonyms: GSK2830371,GSK 2830371,GSK-2830371
Chemical Name: (S)-5-((5-chloro-2-methylpyridin-3-ylamino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide
Storage: 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Note: Products for research use only, not for human use
Description:
In the PPM1D-amplified MCF7 breast carcinoma cells, GSK2830371 increases the phosphorylation of multiple Wip1 substrates, including p53 (S15), Chk2 (T68), H2AX (S139) and ATM (S1981). GSK2830371 shows selective antiproliferative activity in a subset of lymphoid cell lines, all of which carry a wild-type TP53 allele. Furthermore, co-treatment of doxorubicin and GSK2830371 results in a synergistic antiproliferative effect in DOHH2 and MX-1 tumor cells. In vivo, GSK2830371 increases phosphorylation of Chk2 (T68) and p53 (S15) and decreases Wip1 protein concentrations in DOHH2 tumors. GSK2830371 (150 mg/kg p.o.) also inhibits the growth of DOHH2 tumor xenografts via inhibition of Wip1. For the detailed information of GSK2830371, the solubility of GSK2830371 in water, the solubility of GSK2830371 in DMSO, the solubility of GSK2830371 in PBS buffer, the animal experiment (test) of GSK2830371, the cell expriment (test) of GSK2830371, the in vivo, in vitro and clinical trial test of GSK2830371, the EC50, IC50,and affinity,of GSK2830371, For the detailed information of GSK2830371, the solubility of GSK2830371 in water, the solubility of GSK2830371 in DMSO, the solubility of GSK2830371 in PBS buffer, the animal experiment (test) of GSK2830371, the cell expriment (test) of GSK2830371, the in vivo, in vitro and clinical trial test of GSK2830371, the EC50, IC50,and affinity,of GSK2830371, Please contact DC Chemicals.
References:
About us Products Services ordering sitemap
Phone: 18187909333Fax: +86-21-61642470
ADD:Room 610, Building 15, Jinxiang Rd 201, Pudong,Shanghai, China
CopyRight-2010-2013 皇家国际客服--皇家国际客服_18187909333