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HS-27
DC10831  (CAS:N/A)
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25mg USD 950 In stock
50mg USD 1700 In stock
100mg USD 2800 In stock
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Fields of Application :
Hs-27 is a Novel Hsp90 Inhibitor, Exhibits Diagnostic and Therapeutic Potential in Triple Negative Breast Cancer.
CAS Number: N/A
Purity:

0.9

Molecular Weight: 992.4
Molecular Formula: C52H60N6O12S
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: HS27,HS-27,HS 27
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
Hsp90 has emerged as an attractive anti-cancer target. Triple negative breast cancer (TNBC) is a highly aggressive and difficult to treat subtype of breast cancer. Because TNBC is unresponsive to hormone therapies, there are no good therapy options available. Thus, Hsp90 may serve as a reasonable target for TNBC. Hs-27 is a novel Hsp90 inhibitor made by Dr. Timothy Haystead of Duke Universitys Department of Pharmacology and Cancer Biology. It was developed with a fluorescein contrast agent, which makes it suitable for diagnostics. Preliminary experiments with Hs-27 with breast cancer cell lines of different receptor subtypes show that it binds to ectopically expressed Hsp90 in tumor cells. In vitro therapy experiments also show that Hs-27 down-regulates client proteins implicated in tumor growth. In this study, I further establish Hs-27s diagnostic and therapeutic ability in vivo through hyperspectral and fluorescence imaging in dorsal skinfold window chamber tumor models in mice. Largely, I observed that at lower doses, Hs-27 allows for real-time, non-invasive imaging for cancer detection and at higher doses has the potential for therapeutic benefits.
References:
CC1=NN(C2=C1C(=O)CC(C2)(C)C)C3=CC(=C(C=C3)C(=O)N)NCCCOCCOCCOCCOCCOCCCNC(=S)NC4=CC5=C(C=C4)C6(C7=C(C=C(C=C7)O)OC8=C6C=CC(=C8)O)OC5=O
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