H-89 2HCl

  Cat. No.:  DC7835   Featured
H-89 2HCl
Chemical Structure
130964-39-5
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More than 5000 active chemicals with high quality for research!
Field of application
H 89 2HCl is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG, greater than 500-fold selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II.
Cas No.: 130964-39-5
Chemical Name: (E)-N-(2-(4-bromocinnamylamino)ethyl)isoquinoline-5-sulfonamide dihydrochloride
Synonyms: Protein kinase inhibitor H-89 dihydrochloride; H89 dihydrochloride,H 89
SMILES: C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNC/C=C/C3=CC=C(C=C3)Br.Cl.Cl
Formula: C20H20BrN3O2S.2HCl
M.Wt: 519.28
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: H89 2HCl is a potent PKA (cAMP-dependent) protein kinase A inhibitor with Ki of 48 nM, exhibits 10-fold selectivity over PKG, exhibits >500-fold selectivity over PKC, MLCK, calmodulin kinase II and casein kinase I/II. Pretreatment of the cells with H-89 (30 μM) 1 h before the addition of forskolin markedly inhibits the forskolin-induced protein phosphorylation in a dose-dependent manner. H89 also inhibits several other kinases with IC50 of 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b, respectively. H89 also has activity at some cellular receptors and ion channels, including Kv1.3 K+ channels,β1AR and β2AR. H89 causes distinct modifications of protein phosphorylation, with the most robust changes in phosphorylation are fructose-1,6-biphosphatase, heterogeneous nuclear ribonucleoprotein (hnRNP), NSFL1 cofactor p47, all which have potentially regulatory connections to cAMP/PKA. H-89 (0.5, 1, 5 mg/kg) significantly attenuates prominent behavioral signs of morphine withdrawal in morphine-dependent mice.For the detailed information of H-89 2HCl, the solubility of H-89 2HCl in water, the solubility of H-89 2HCl in DMSO, the solubility of H-89 2HCl in PBS buffer, the animal experiment (test) of H-89 2HCl, the cell expriment (test) of H-89 2HCl, the in vivo, in vitro and clinical trial test of H-89 2HCl, the EC50, IC50,and affinity,of H-89 2HCl, Please contact DC Chemicals.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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