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LY2955303
DC10833  (CAS:1433497-19-8 )
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Fields of Application :
LY2955303 is a potent and selective RAR-gamma antagonist for the treatment of osteoarthritis pain.
CAS Number: 1433497-19-8
Purity:

>98%

Molecular Weight: 578.32
Molecular Formula: C36H42N4O3
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: LY2955303; LY-2955303; LY 2955303
Chemical Name: 4-(5-(3,5-di-tert-butylphenyl)-1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-1H-pyrazol-3-yl)benzoic acid
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
LY2955303 is a potent and selective RAR-gamma antagonist for the treatment of osteoarthritis pain. LY2955303 has RAR-gamma Ki = 1.09 nM; RAR-alpha Ki > 1700 nM; RAR-beta Ki > 2980 nM. LY2955303 demonstrated good pharmacokinetic properties and was efficacious in the MIA model of osteoarthritis-like joint pain. LY2955303 demonstrated an improved margin to RAR -mediated adverse effects.
References:
O=C(O)C1=CC=C(C2=NN(C3=CC=C(C(N4CCN(C)CC4)=O)C=C3)C(C5=CC(C(C)(C)C)=CC(C(C)(C)C)=C5)=C2)C=C1
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