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LYN-1604
DC10715  (CAS:2088939-99-3)
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100mg $650.00 In stock
250mg $1100.00 In stock
1g $2100.00 In stock
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Fields of Application :
LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 M against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM).
CAS Number: 2088939-99-3
Purity:

>98%

Molecular Weight: 657.54
Molecular Formula: C33H45Cl4N3O2
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: LYN-1604,LYN 1604,LYN1604
Chemical Name: 2-?[bis(2-?methylpropyl)?amino]?-?1-?[4-?[2-?(2,?4-?dichlorophenyl)?-?2-?(2-?naphthalenylmethoxy)?ethyl]?-?1-?piperazinyl]?-Ethanone dihydrochloride
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
LYN-1604 is a ULK1 agonist. Three amino acid residues (LYS50, LEU53, and TYR89) are key to the activation site of LYN-1604 and ULK1 by site-directed mutagenesis and biochemical assays. LYN-1604 induces cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 is bound to wild-type ULK1 with a binding affinity in the nanomole range (KD = 291.4 nM), but the ULK1Y89A mutant protein causes a sharp decrease in binding affinity with lower response and Kd than wild-type ULK1, ULK1K50A and ULK1L53A mutants[1].LYN-1604 could significantly inhibit the growth of xenograft MDA-MB-231 cells. LYN-1604 can directly activate ULK1, the initiator of autophagy, thereby inducing cell death to inhibit the growth of TNBC in vitro and in vivo[1].
References:
C1=C(COC(C2=CC=C(Cl)C=C2Cl)CN2CCN(C(=O)CN(CC(C)C)CC(C)C)CC2)C=CC2C=CC=CC1=2.Cl.Cl
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