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MA-0204
DC12034  (CAS:2095128-17-7)
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Fields of Application :
MA-0204 is a potent, selective PPAR modulator with good pharmacokinetic properties.
CAS Number: 2095128-17-7
Purity:

>98%

Molecular Weight: 476.19
Molecular Formula: C25H27F3N2O4
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: B 973B-973B9732244989-34-0
Chemical Name: (R)-3-methyl-6-(2-((5-methyl-2-(4-(trifluoromethoxy)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
MA-0204 is a highly potent and selective PPARd modulator (PPAR EC50 = 0.4 nM; PPARalpha, EC50 == 6,660 nM) that upregulates the expression of FAO genes in human renal proximal tubule cells, resulting in increased mitochondrial fatty acid oxidation. In normal rats undergoing IR-AKI, MA-0204 attenuates the increases of plasma and urinary biomarkers of AKI, improves renal function, mitigates proximal tubular damage and boosts mitochondrial gene expression. MA-0204 is a potential Treatment for Duchenne Muscular Dystrophy (DMD)
References:
O=C(O)C[C@H](C)CCCOC1=CC=CC=C1CN2C(C)=CN=C2C3=CC=C(OC(F)(F)F)C=C3
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