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MAZ51
DC11285  (CAS:163655-37-6)
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100mg USD 550 in stock
250mg USD 900 in stock
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Fields of Application :
MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 M) without blocking VEGFC-mediated stimulation of VEGFR2.
CAS Number: 163655-37-6
Purity:

>98%

Molecular Weight: 314.4
Molecular Formula: C21H18N2O
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: MAZ51,MAZ-51,MAZ 51
Chemical Name: 3-[[4-(dimethylamino)-1-naphthalenyl]methylene]-1,3-dihydro-2H-indol-2-one
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 M) without blocking VEGFC-mediated stimulation of VEGFR2.It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFR.By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA. It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo. MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival.
References:
CN(C)C1=C(C=CC=C2)C2=C(/C=C3C(NC4=C/3C=CC=C4)=O)C=C1
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