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ML297 (VU0456810)
DC10849  (CAS:1443246-62-5)
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Fields of Application :
ML297 (VU0456810) is the First Potent and Selective Activator of the GIRK Potassium Channel, Displays Antiepileptic Properties in Mice.
CAS Number: 1443246-62-5
Purity:

>98%

Molecular Weight: 328.32
Molecular Formula: C17H14F2N4O
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: ML 297,ML-297,ML297,VU0456810,VU-0456810,VU 0456810
Chemical Name: N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
Selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). Exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters. Prevents PTZ-induced epileptic seizures in mice. Brain penetrant.
References:
O=C(NC2=CC(C)=NN2C3=CC=CC=C3)NC1=CC(F)=C(F)C=C1
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