MSA-2

  Cat. No.:  DC39031   Featured
MSA-2
Chemical Structure
129425-81-6
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Field of application
MSA-2 is an orally available human STING agonist.MSA-2 is bound to STING as a noncovalent dimer. Extensive experimental analysis indicates that MSA-2 predimerization is required for binding. Acidic tumor microenvironments favor permeable, uncharged MSA-2. Intracellular MSA-2 is "trapped" and accumulation drives MSA-2 dimerization, preferentially activating STING intratumorally. Orally dosed MSA-2 is well tolerated in mice, exhibiting STING-dependent antitumor activity, as monotherapy and combined with antibodies against PD1 (anti-PD1).
Cas No.: 129425-81-6
Chemical Name: 5,6-dimethoxy-γ-oxo-benzo[b]thiophene-2-Butanoic Acid
Synonyms: MSA-2;MSA 2;MSA2
SMILES: O=C(C1=CC(C(S1)=C2)=CC(OC)=C2OC)CCC(O)=O
Formula: C14H14O5S
M.Wt: 294.32
Purity: >99%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Altman, M.D., Cash, B.D., Chang, W., et al. Benzo[B]thiophene compounds as STING agonists. (2018). 2. Pan, B.-S., Perera, S.A., Piesvaux, J.A., et al. An orally available non-nucleotide STING agonist with antitumor activity. Science 369(6506), eaba6098 (2020).
Description:
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC39031 MSA-2 MSA-2 is an orally available human STING agonist.MSA-2 is bound to STING as a noncovalent dimer. Extensive experimental analysis indicates that MSA-2 predimerization is required for binding. Acidic tumor microenvironments favor permeable, uncharged MSA-2. Intracellular MSA-2 is "trapped" and accumulation drives MSA-2 dimerization, preferentially activating STING intratumorally. Orally dosed MSA-2 is well tolerated in mice, exhibiting STING-dependent antitumor activity, as monotherapy and combined with antibodies against PD1 (anti-PD1).
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