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NGI-1 (ML414)
DC11281  (CAS:790702-57-7)
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Fields of Application :
NGI-1 (ML414) is a potent, cell-permeable oligosaccharyltransferase (OST) inhibitor with IC50 of 1.1 uM.
CAS Number: 790702-57-7
Purity:

>98%

Molecular Weight: 394.51
Molecular Formula: C17H22N4O3S2
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: NGI-1; NGI1; NGI 1; ML414; ML 414; ML-414
Chemical Name: 5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
Novel cell-permeable inhibitor of oligosaccharyltransferase (OST), blocking cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein in non-small-cell lung cancer cells, but selectively arresting proliferation in only those cell lines that are dependent on EGFR (or fibroblast growth factor, FGFR) for survival
References:
O=C(NC1=NC=C(C)S1)C2=CC(S(=O)(N(C)C)=O)=CC=C2N3CCCC3
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