NVP-AEW541

  Cat. No.:  DC4174  
NVP-AEW541
Chemical Structure
475489-16-8
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More than 5000 active chemicals with high quality for research!
Field of application
NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM.
Cas No.: 475489-16-8
Chemical Name: 7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Synonyms: AEW541,NVP AEW541
SMILES: NC1=C2C(N([C@@H]3C[C@@H](C3)CN4CCC4)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
Formula: C27H29N5O
M.Wt: 439.55
Purity: 99%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: NVP-AEW541 is a pyrrolo[2,3-d]pyrimidine derivative small molecular weight kinase inhibitor of the IGF-IR, capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. As expected For a specific IGF-IR kinase inhibitor, NVP-AEW541 abrogates IGF-I-mediated survival and colony Formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. In vivo, this orally bioavailable compound inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas. Thus, NVP-AEW541 represents a class of selective, small molecule IGF-IR kinase inhibitors with proven in vivo antitumor activity and potential therapeutic application. (Source: García-Echeverría C, Pearson MA, Marti A, Meyer T, Mestan J, Zimmermann J, Gao J, Brueggen J, Capraro HG, Cozens R, Evans DB, Fabbro D, Furet P, Porta DG, Liebetanz J, Martiny-Baron G, Ruetz S, Hofmann F. Cancer Cell. 2004 Mar;5(3):231-9.) For the detailed information about the solubility of NVP-AEW541 in water, the solubility of NVP-AEW541 in DMSO, the solubility of NVP-AEW541 in PBS buffer, the animal experiment(test) of NVP-AEW541, the in vivo,in vitro and clinical trial test of NVP-AEW541, the cell experiment(test) of NVP-AEW541, the IC50, EC50 and Affinity of NVP-AEW541 , please contact DC Chemicals.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC4174 NVP-AEW541 NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM.