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NVP-AEW541
DC4174  (CAS:475489-16-8)
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Fields of Application :
NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM.
CAS Number: 475489-16-8
Purity:

99%

Molecular Weight: 439.55
Molecular Formula: C27H29N5O
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: AEW541,NVP AEW541
Chemical Name: 7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
NVP-AEW541 is a pyrrolo[2,3-d]pyrimidine derivative small molecular weight kinase inhibitor of the IGF-IR, capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. As expected For a specific IGF-IR kinase inhibitor, NVP-AEW541 abrogates IGF-I-mediated survival and colony Formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. In vivo, this orally bioavailable compound inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas. Thus, NVP-AEW541 represents a class of selective, small molecule IGF-IR kinase inhibitors with proven in vivo antitumor activity and potential therapeutic application. (Source: Garca-Echeverra C, Pearson MA, Marti A, Meyer T, Mestan J, Zimmermann J, Gao J, Brueggen J, Capraro HG, Cozens R, Evans DB, Fabbro D, Furet P, Porta DG, Liebetanz J, Martiny-Baron G, Ruetz S, Hofmann F. Cancer Cell. 2004 Mar;5(3):231-9.) For the detailed information about the solubility of NVP-AEW541 in water, the solubility of NVP-AEW541 in DMSO, the solubility of NVP-AEW541 in PBS buffer, the animal experimenttest of NVP-AEW541, the in vivo,in vitro and clinical trial test of NVP-AEW541, the cell experimenttest of NVP-AEW541, the IC50, EC50 and Affinity of NVP-AEW541 , please contact DC Chemicals.
References:
NC1=C2C(N([C@@H]3C[C@@H](C3)CN4CCC4)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
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