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Nutlin-3a
DC8454  (CAS:675576-98-4)
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100mg USD 700 In stock
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1g USD 2600 In stock
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Fields of Application :
Nutlin-3a is arbitrarily referred to as enantiomer a because it appears as the first peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known.
CAS Number: 675576-98-4
Purity:

>97%

Molecular Weight: 581.49
Molecular Formula: C30H30Cl2N4O4
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: nutlin3a,Nutlin 3a,(-)nutlin-3
Chemical Name: 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
Nutlin-3a is arbitrarily referred to as enantiomer a because it appears as the first peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. It potently inhibits Mdm2-p53 binding with an IC50 value of 0.09 M, induces the expression of p53-regulated genes, and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. (?)-Nutlin-3 inhibits the proliferation of exponentially growing human skin and murine fibroblasts with IC50 values of 2.2 and 1.3 M, respectively, and induces substantial tumor shrinkage in mice expressing LnCaP, 22Rv1 or MHM cancer cell lines when treated orally with a 200 mg/kg dose twice daily for two weeks. For the detailed information of Nutlin-3a, the solubility of Nutlin-3a in water, the solubility of Nutlin-3a in DMSO, the solubility of Nutlin-3a in PBS buffer, the animal experiment (test) of Nutlin-3a, the cell expriment (test) of Nutlin-3a, the in vivo, in vitro and clinical trial test of Nutlin-3a, the EC50, IC50,and affinity,of Nutlin-3a, For the detailed information of Nutlin-3a, the solubility of Nutlin-3a in water, the solubility of Nutlin-3a in DMSO, the solubility of Nutlin-3a in PBS buffer, the animal experiment (test) of Nutlin-3a, the cell expriment (test) of Nutlin-3a, the in vivo, in vitro and clinical trial test of Nutlin-3a, the EC50, IC50,and affinity,of Nutlin-3a, Please contact DC Chemicals.
References:
N1CCN(C(N2C(C3=CC=C(OC)C=C3OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]2C2=CC=C(Cl)C=C2)=O)CC1=O
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