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PF-06869206
DC10834  (CAS:N/A)
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Fields of Application :
PF-06869206 is an Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1).
CAS Number: N/A
Purity:

>98%

Molecular Weight: 374.07
Molecular Formula: C15H14ClF3N4O2
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: PF-06869206; PF 06869206; PF06869206
Chemical Name: (S)-3-chloro-7-(2-(hydroxymethyl)morpholino)-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
Sodium-phosphate cotransporter 2a, or NaPi2a (SLC34A1), is a solute-carrier (SLC) transporter located in the kidney proximal tubule that reabsorbs glomerular-filtered phosphate. Inhibition of NaPi2a may enhance urinary phosphate excretion and correct maladaptive mineral and hormonal derangements associated with increased cardiovascular risk in chronic kidney diseaseCmineral and bone disorder (CKD-MBD).PF-06869206 is the first orally bioavailable selective NaPi2a inhibitor and, as such, represents a pharmacological tool to probe the functional effects of selective NaPi2a inhibition in vivo. PF-06869206 showed a balance of attributes with 380 nM NaPi2a inhibition potency, excellent subtype selectivity, and acceptable aqueous solubility (46 M). Furthermore, permeability is good (14 10?6 cm/s), and RLM clearance is low (<14 L/min/mg; HLM = 39 L/min/mg).
References:
N#CC1=C(C(F)(F)F)N=C2C(NC(C)=C2Cl)=C1N3C[C@@H](CO)OCC3
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