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Rp-8-bromo-Cyclic AMPS
DC11480  (CAS:925456-59-3)
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Fields of Application :
Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.
CAS Number: 925456-59-3
Purity:

>98%

Molecular Weight: 446.1
Molecular Formula: C10H10BrN5O5PS.Na
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: Rp-8-Br-cAMPS,8-Bromoadenosine 3',5'-cyclic monophosphorothioate, Rp-isomer,Rp-8-bromo-cAMPS,925456-59-3
Chemical Name: 8-bromo-adenosine cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate], monosodium salt
Storage: 4 Degree for 1 year, -20 degree for more than 2 years
Note: Products for research use only, not for human use
Description:
Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.
References:
O[C@H]1[C@H](N2C(Br)=NC3=C2N=CN=C3N)O[C@H]4[C@H]1O[P@@](OC4)([S-])=O.[Na+]
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