Cat. No.:  DC39262   Featured
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
SBP-7455 is an orally active dual-specific ULK1/2 autophagy inhibitor with improved binding affinity compared with SBI-0206965.
Cas No.: 1884222-74-5
Chemical Name: 2,​4-​Pyrimidinediamine, N4-​cyclopropyl-​N2-​(3,​4-​dimethoxyphenyl)​-​5-​(trifluoromethyl)​-
Synonyms: SBP-7455;SBP 7455;SBP7455
Formula: C16H17F3N4O2
M.Wt: 354.33
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1 Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer--Huiyu Ren 1, Nicole A Bakas 1, Mitchell Vamos 1, Apirat Chaikuad 2 3, Allison S Limpert 1, Carina D Wimer 1, Sonja N Brun 4, Lester J Lambert 1, Lutz Tautz 1, Maria Celeridad 1, Douglas J Sheffler 1, Stefan Knapp 2 3, Reuben J Shaw 4, PMID: 33200929 DOI: 10.1021/acs.jmedchem.0c00873
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Cat. No. Product name Field of application
DC50010 ICCB280 ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc).
DC50005 CH7233163 CH7233163 is a novel selective inhibitor of various types of EGFR mutants including L858R/T790M/C797S, L858R/T790M, Del19/T790M, Del19, and L858R, showing potent antitumor activities
DC50004 Periplocin Periplocin is a cardiotonic steroid isolated from Periploca forrestii. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase.
DC50003 Monastrol Potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC50 = 14 μM).
DC50002 EDP-305 EDP-305 is a novel and potent farnesoid X receptor (FXR) agonist, with no/minimal cross-reactivity to TGR5 or other nuclear receptors.
DC50001 UCB-9260 UCB-9260, an orally active compound, inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM.
DC30003 VBIT-12 VBIT-12 is a potent inhibitor of VDAC1, directly interacting with purified VDAC1 and reducing its channel conductance.
DC39827 Entecavir Enantiomer Enantiomer of Entecavir
DC39235 Fmoc-Val-Ala-PAB-OH Fmoc-Val-Ala-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
DC39826 Homo-PROTAC cereblon degrader 1 Homo-PROTAC cereblon degrader 1, is a cereblon degrader.