SBP-7455

  Cat. No.:  DC39262   Featured
SBP-7455
Chemical Structure
1884222-74-5
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Field of application
SBP-7455 is an orally active dual-specific ULK1/2 autophagy inhibitor with improved binding affinity compared with SBI-0206965.
Cas No.: 1884222-74-5
Chemical Name: 2,​4-​Pyrimidinediamine, N4-​cyclopropyl-​N2-​(3,​4-​dimethoxyphenyl)​-​5-​(trifluoromethyl)​-
Synonyms: SBP-7455;SBP 7455;SBP7455
SMILES: C1N=C(NC2C=CC(OC)=C(OC)C=2)N=C(NC2CC2)C=1C(F)(F)F
Formula: C16H17F3N4O2
M.Wt: 354.33
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1 Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer--Huiyu Ren 1, Nicole A Bakas 1, Mitchell Vamos 1, Apirat Chaikuad 2 3, Allison S Limpert 1, Carina D Wimer 1, Sonja N Brun 4, Lester J Lambert 1, Lutz Tautz 1, Maria Celeridad 1, Douglas J Sheffler 1, Stefan Knapp 2 3, Reuben J Shaw 4, PMID: 33200929 DOI: 10.1021/acs.jmedchem.0c00873
Description:
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MSDS
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MSDS_20559_DC39262_1884222-74-5
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