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SB-334867
DC8419  (CAS:792173-99-0)
(Based on popularity)
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100mg USD 350 In stock
250mg USD 700 In stock
1g USD 1450 In stock
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Fields of Application :
SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
CAS Number: 792173-99-0
Purity:

>98%

Molecular Weight: 319.32
Molecular Formula: C17H13N5O2
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: SB334867,SB 334867,SB-334867
Chemical Name: 1-(2-methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
In CHO-OX1 cells, SB-334867 inhibits the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses with pKB of 7.27 and 7.23 respectively, without effect on the UTP (3 microM)-induced calcium response. In both male and female rats, SB-334867 (30 mg/kg, i.p.) significantly reduces natural and orexin-A-induced food intake. SB-334867 (2 mg/kg, i.v.) blocks the effects of antipsychotic drugs on dopamine neuronal activity in rats. SB-334867 also inhibits the development of morphine analgesic tolerance in rats. For the detailed information of SB-334867, the solubility of SB-334867 in water, the solubility of SB-334867 in DMSO, the solubility of SB-334867 in PBS buffer, the animal experiment (test) of SB-334867, the cell expriment (test) of SB-334867, the in vivo, in vitro and clinical trial test of SB-334867, the EC50, IC50,and affinity,of SB-334867, For the detailed information of SB-334867, the solubility of SB-334867 in water, the solubility of SB-334867 in DMSO, the solubility of SB-334867 in PBS buffer, the animal experiment (test) of SB-334867, the cell expriment (test) of SB-334867, the in vivo, in vitro and clinical trial test of SB-334867, the EC50, IC50,and affinity,of SB-334867, Please contact DC Chemicals.
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