SKL2001

  Cat. No.:  DC10888   Featured
SKL2001
Chemical Structure
909089-13-0
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More than 5000 active chemicals with high quality for research!
Field of application
SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity.
Cas No.: 909089-13-0
Chemical Name:
Synonyms: SKL2001,SKL-2001,SKL 2001
SMILES: O=C(C1=NOC(C2=CC=CO2)=C1)NCCCN3C=CN=C3
Formula: C14H14N4O3
M.Wt: 286.29
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: SKL2001 is an agonist of the Wnt/β-catenin pathway, and also upregulates the expression of Axin2, a downstream target of the Wnt/β-catenin pathway, but shows no effect on NF-κB, p53 reporter activity and GSK-3β activity. SKL2001 causes osteoblast differentiation (20 and 40 μM) and suppresses preadipocyte differentiation (5, 10, and 30 μM) via the activation of the Wnt/β-catenin pathway. SKL2001 (5, 10, and 30 μM) stabilizes intracellular β-catenin in 3T3-L1 cells. SKL2001 (40 μM) significantly inhibits the proliferation of HCT116 spheroids independently of cytotoxicity and the inhibition is reversible; SKL2001 cuases cell cycle arrest in HCT116 spheroids. SKL2001 (40 μM) enhances round-shape spheroid formation and E-cadherin expression.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC10888 SKL2001 SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity.